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By Robert K. Ockner

advanced and unexplained phenomena are inclined to foster unorthodox views. This booklet is an instance, as is a previous ebook that emphasised the concept middleman metabolism may play an important and opting for function in hepatocyte proliferation and 1 tumorigenesis. formula of this speculation was once in accordance with an try and make clear numerous poorly understood phenomena; together with the observations: 1) that xenobiotic peroxisome proliferators resembling the fibrate hypolipidemic brokers result in hepatocyte proliferation and carcinogenesis in rodents; 2) that benign and malignant liver tumors complicate the human syndrome of glycogen garage illness sort I (glucose-6-phosphatase deficiency); and three) that during this comparable syndrome, management of glucose exerts an anti-tumor impact. Fatty acid and glucose metabolism are tightly associated in a we- tested and profoundly inportant interaction. This connection, including the truth that peroxisome proliferator-induced hepatocyte proliferation and carcinogenesis displays inhibition of mitochondrial carnitine palmitoyltransferase-I and fatty acid oxidation, recommended the chance that legislation of fatty acid metabolism may possibly end up to be a pivotal determinant within the regulate of phone development. In 1993, the yr during which the paper brought up above used to be released, perception into the significance of progress components and sign transduction pathways in phone cycle law used to be expanding quickly, yet metabolic and lively facets of cellphone proliferation had attracted particularly little realization. regardless of this, the concept that appeared inescapable that the 2 doubtless special and unrelated determinants — sign transduction and metabolism — have been integrally linked.

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