Download The Chemical Biology of Nucleic Acids by Günter Mayer PDF

By Günter Mayer

With wide assurance of synthesis concepts and functions, this article describes chemical biology innovations that have received major impetus over the past 5 years. It makes a speciality of the equipment for acquiring changed and local nucleic acids, and their organic functions. subject matters lined comprise:

  • chemical synthesis of converted RNA
  • expansion of the genetic alphabet in nucleic acids through developing new base pairs
  • chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with changed nucleotides
  • nucleic-acid-templated chemistry
  • chemical biology of peptide nucleic acids (PNA)
  • the interactions of small molecules with DNA and RNA
  • the architectural modules of folded RNAs
  • genesis and organic purposes of locked nucleic acid (LNA)
  • small non-coding RNA in bacteria
  • microRNA-guided gene silencing
  • nucleic acids established therapies
  • innate immune attractiveness of nucleic acid
  • light-responsive nucleic acids for the spatiotemporal keep watch over of organic processes
  • DNA methylation
  • frameworks for programming RNA devices
  • RNA as a catalyst: The Diels-Alderase-Ribozyme
  • evolving an knowing of RNA functionality by way of in vitro approaches
  • the chemical biology of aptamers: synthesis and applications
  • nucleic acids as detection tools
  • bacterial riboswitch discovery and analysis

The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their organic functions for bioorganic chemists, chemical biologists, medicinal chemists, mobile biologists, and molecular biologists.

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